TY  - EJOU
AU  - Yue, Min  
AU  - Stachowiak, Jeanne C.  
AU  - Majumdar, Arunava  

TI  - Cantilever Arrays for Multiplexed Mechanical Analysis of Biomolecular Reactions
T2  - Molecular \& Cellular Biomechanics

PY  - 2004
VL  - 1
IS  - 3
SN  - 1556-5300

AB  - Microchips;ontaining arrays of cantilever beams have been used to mechanically detect and quantitatively analyze multiple reactions of DNA hybridization and antigen-antibody binding simultaneously. The reaction-induced deflection of a cantilever beam reflects the interplay between strain energy increase of the beam and the free energy reduction of a reaction, providing an ideal tool for investigating the connection between mechanics and chemistry of biomolecular reactions. Since free energy reduction is common for all reactions, the cantilever array forms a universal platform for label-free detection of various specific biomolecular reactions. A few such reactions and their implications in biology and biotechnology are discussed.
KW  - Cantilevers
KW  -  array
KW  -  DNA hybridization
KW  -  protein interaction
KW  -  multiplexing

DO  - 10.3970/mcb.2004.001.211