@Article{mcb.2008.005.119,
AUTHOR = {Gretchen J. McAuliffe, Jung Yun Chang, Raymond P. Glahn, Michael L. Shuler},
TITLE = {Development of a Gastrointestinal Tract Microscale Cell Culture Analog to Predict Drug Transport},
JOURNAL = {Molecular \& Cellular Biomechanics},
VOLUME = {5},
YEAR = {2008},
NUMBER = {2},
PAGES = {119--132},
URL = {http://www.techscience.com/mcb/v5n2/28464},
ISSN = {1556-5300},
ABSTRACT = {Microscale cell culture analogs (<i>μ</i>CCAs) are used to study the metabolism and toxicity of a chemical or drug. These <i>in vitro</i> devices are physical replicas of physiologically based pharmacokinetic models that combine microfabrication and cell culture. The goal of this project is to add an independent GI tract <i>μ</i>CCA to a multi-chamber chip <i>μ</i>CCA representing the primary circulation. The GI tract <i>μ</i>CCA consists of two chambers separated by a microporous membrane on which intestinal epithelial cells are cultured. Compounds of interest are pumped through the top chamber, allowing drug to be absorbed through the epithelial layer and circulated into the chip <i>μ</i>CCA. The chip and GI tract <i>μ</i>CCAs have been used to recreate the toxic effects of acetaminophen. Preliminary results have shown that the GI tract <i>μ</i>CCA acts as a barrier to drugs entering the chip, mimicking <i>in vivo</i> function in this regard.},
DOI = {10.3970/mcb.2008.005.119}
}