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Cyclic Bending Contributes to High Stress in a Human Coronary Atherosclerotic Plaque and Rupture Risk: In Vitro Experimental Modeling and Ex Vivo MRI-Based Computational Modeling Approach

Chun Yang∗,†, Dalin Tang∗,‡, Shunichi Kobayashi§, Jie Zheng, Pamela K. Woodard§, Zhongzhao Teng*, Richard Bach||, David N. Ku∗∗

Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609
Schoolof MathematicalSciences,Beijing NormalUniversity, Beijing, China
Corresponding author. Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, Phone: 508-831-5332, Fax: 508-831-5824, E-mail: dtang@wpi.edu
§ Division of Creative Engineering, Shinshu University, Ueda, Nagano, Japan
Mallinkcrodt Inst. of Radiology, Washington University, St. Louis, MO 63110, USA
|| Division of Cardiovascular Diseases, Washington University, St. Louis, MO 63110, USA
∗∗ School of Mechanical Engineering, Georgia Institute of Technology,Atlanta, GA, 30332-0405USA

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