TY  - EJOU
AU  - Liu, Biyue 
AU  - Tang, Dalin 

TI  - Computer Simulations of Atherosclerotic Plaque Growth in Coronary Arteries
T2  - Molecular \& Cellular Biomechanics

PY  - 2010
VL  - 7
IS  - 4
SN  - 1556-5300

AB  - A three dimensional mathematical model with a linear plaque growth function was developed to investigate the geometrical adaptation of atherosclerotic plaques in coronary arteries and study the influences of flow wall shear stress (WSS), blood viscosity and the inlet flow rate on the growth of atherosclerotic plaques using computational plaque growth simulations. The simulation results indicated that the plaque wall thickness at the neck of the stenosis increased at a decreasing rate in the atherosclerosis progression. The simulation results also showed a strong dependence of the plaque wall thickness increase on the blood viscosity and the inlet flow rate. The progression rate in a coronary artery was lower with a higher inlet velocity flow rate and higher with a smaller value of the blood viscosity.
KW  - coronary artery
KW  -  plaque wall thickness increase
KW  -  blood flow simulation
KW  -  plaque progression
KW  -  wall shear stress

DO  - 10.3970/mcb.2010.007.193