@Article{mcb.2010.007.203,
AUTHOR = {F.E. Mensah, R. Sridhar, P.  Misra},
TITLE = {Simulation and Modeling of Laser-Tissue Interactions Based on a Liposome-Dye System},
JOURNAL = {Molecular \& Cellular Biomechanics},
VOLUME = {7},
YEAR = {2010},
NUMBER = {4},
PAGES = {203--212},
URL = {http://www.techscience.com/mcb/v7n4/28507},
ISSN = {1556-5300},
ABSTRACT = {This work presents an overview of the use of liposomes for targeted delivery of photosensitizers to tumors for Photodynamic Therapy (PDT). It assesses the results of a quantitative model to explain the interaction of short-pulsed lasers (in the nanosecond and picosecond domains) with a liposome-dye complex in terms of a localized photo-induced thermal mechanism. Incorporation of an organic dye (sulforhodamine) within lipid vesicles has been investigated in conjunction with the effect of laser irradiation on the integrity of the liposome-dye complex. The variation of the absorption coefficient as a function of wavelength for dye-encapsulated liposomes before and after laser-induced release of dye was studied and modeled. The commercial softwareMathematicawas used to develop a Gaussian model for the energy absorption by the liposome-dye complex. Dye release from 3mm - liposome encapsulating 25 mM aqueous solution of sulforhodamine dye was studied using 8 ns laser pulses at the second harmonic of the Nd:YAG laser (at 532 nm) and compared with dye release employing 25 ps - laser pulses. In addition, the temperature-dependence of the dye release has been included in the photo-thermal model.},
DOI = {10.3970/mcb.2010.007.203}
}