TY  - EJOU
AU  - Mensah, F.E. 
AU  - Sridhar, R. 
AU  - Misra, P.  

TI  - Simulation and Modeling of Laser-Tissue Interactions Based on a Liposome-Dye System
T2  - Molecular \& Cellular Biomechanics

PY  - 2010
VL  - 7
IS  - 4
SN  - 1556-5300

AB  - This work presents an overview of the use of liposomes for targeted delivery of photosensitizers to tumors for Photodynamic Therapy (PDT). It assesses the results of a quantitative model to explain the interaction of short-pulsed lasers (in the nanosecond and picosecond domains) with a liposome-dye complex in terms of a localized photo-induced thermal mechanism. Incorporation of an organic dye (sulforhodamine) within lipid vesicles has been investigated in conjunction with the effect of laser irradiation on the integrity of the liposome-dye complex. The variation of the absorption coefficient as a function of wavelength for dye-encapsulated liposomes before and after laser-induced release of dye was studied and modeled. The commercial softwareMathematicawas used to develop a Gaussian model for the energy absorption by the liposome-dye complex. Dye release from 3mm - liposome encapsulating 25 mM aqueous solution of sulforhodamine dye was studied using 8 ns laser pulses at the second harmonic of the Nd:YAG laser (at 532 nm) and compared with dye release employing 25 ps - laser pulses. In addition, the temperature-dependence of the dye release has been included in the photo-thermal model.
KW  - Liposome
KW  -  PDT
KW  -  laser
KW  -  dye
KW  -  sulforhodamine
KW  -  tumor
KW  -  photosensitizer
KW  -  singlet oxygen

DO  - 10.3970/mcb.2010.007.203