TY  - EJOU
AU  - Zhang, T. 

TI  - Cytoplasmic Motion Induced by Cytoskeleton Stretching and Its Effect on Cell Mechanics
T2  - Molecular \& Cellular Biomechanics

PY  - 2011
VL  - 8
IS  - 3
SN  - 1556-5300

AB  - Cytoplasmic motion assumed as a steady state laminar flow induced by cytoskeleton stretching in a cell is determined and its effect on the mechanical behavior of the cell under externally applied forces is demonstrated. Non-Newtonian fluid is assumed for the multiphase cytoplasmic fluid and the analytical velocity field around the macromolecular chain is obtained by solving the reduced nonlinear momentum equation using homotopy technique. The entropy generation by the fluid internal friction is calculated and incorporated into the entropic elasticity based 8-chain constitutive relations. Numerical examples showed strengthening behavior of cells in response to externally applied mechanical stimuli. The spatial distribution of the stresses within a cell under externally applied fluid flow forces were also studied.
KW  - cell cytoplasm cytoskeleton macromolecules non-Newtonian fluid constitutive relation

DO  - 10.3970/mcb.2011.008.169