@Article{mcb.2012.009.077, AUTHOR = {}, TITLE = {IVUS-Based Computational Modeling and Planar Biaxial Artery Material Properties for Human Coronary Plaque Vulnerability Assessment}, JOURNAL = {Molecular \& Cellular Biomechanics}, VOLUME = {9}, YEAR = {2012}, NUMBER = {1}, PAGES = {77--94}, URL = {http://www.techscience.com/mcb/v9n1/28531}, ISSN = {1556-5300}, ABSTRACT = {Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better plaque assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. A framework is proposed to combine intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling with fluid-structure interactions and anisotropic material properties to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. Impact of pre-shrink-stretch process, vessel curvature and high blood pressure on stress, strain, flow velocity and flow maximum principal shear stress was investigated.}, DOI = {10.3970/mcb.2012.009.077} }