TY  - EJOU
AU  - , 

TI  - IVUS-Based Computational Modeling and Planar Biaxial Artery Material Properties for Human Coronary Plaque Vulnerability Assessment
T2  - Molecular \& Cellular Biomechanics

PY  - 2012
VL  - 9
IS  - 1
SN  - 1556-5300

AB  - Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better plaque assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. A framework is proposed to combine intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling with fluid-structure interactions and anisotropic material properties to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. Impact of pre-shrink-stretch process, vessel curvature and high blood pressure on stress, strain, flow velocity and flow maximum principal shear stress was investigated.
KW  - Coronary artery
KW  -  cardiovascular
KW  -  fluid-structure interaction
KW  -  atherosclerotic plaque rupture
KW  -  IVUS

DO  - 10.3970/mcb.2012.009.077