TY  - EJOU
AU  - Wu, Jie 
AU  - Cai, Yan 
AU  - Xu, Shixiong 
AU  - Long, Quan 
AU  - Ding, Zurong 
AU  - Dong, Cheng 

TI  - 3D Numerical Study of Tumor Microenvironmental Flow in Response to Vascular-Disrupting Treatments
T2  - Molecular \& Cellular Biomechanics

PY  - 2012
VL  - 9
IS  - 2
SN  - 1556-5300

AB  - The effects of vascular-disrupting treatments on normalization of tumor microvasculature and its microenvironmental flow were investigated, by mathematical modeling and numerical simulation of tumor vascular-disrupting and tumor haemodynamics. Four disrupting approaches were designed according to the abnormal characteristics of tumor microvasculature compared with the normal one. The results predict that the vascular-disrupting therapies could improve tumor microenvironment, eliminate drug barrier and inhibit metastasis of tumor cells to some extent. Disrupting certain types of vessels may get better effects. In this study, the flow condition on the networks with "vascular-disrupting according to flowrate" is the best comparing with the other three groups, and disrupting vessels of lower maturity could effectively enhance fluid transport across vasculature into interstitial space.
KW  - Solid tumor
KW  -  vascular-disrupting
KW  -  microenvironment normalization
KW  -  haemodynamics
KW  -  3D numerical simulation

DO  - 10.3970/mcb.2012.009.095