@Article{oncologie.2020.012436,
AUTHOR = {Jingjing He, Lingyi Zhang, Dan Guo, Xingwen Han, Hui Zhang, Liang Wang, Youcheng
Zhang},
TITLE = {<i>Sinomenium</i> Inhibits the Viability of Hepatoma Carcinoma Cells through  Activating IFNA2},
JOURNAL = {Oncologie},
VOLUME = {22},
YEAR = {2020},
NUMBER = {1},
PAGES = {1--12},
URL = {http://www.techscience.com/oncologie/v22n1/39626},
ISSN = {1765-2839},
ABSTRACT = {Hepatocellular carcinoma (HCC) ranks the sixth place of most common 
cancers. Meanwhile, it is the tertiary mortality cause of cancer. There is no 
effective therapeutic method to prevent and treat the liver cancer. Sinomenine is a 
kind of Chinese traditional medicine herbal, it is reported that it can inhibit the 
viability of several cancer cells. The study is to explore whether sinomenine is also 
able to inhibit the cell viability of HCC and its potential mechanism. The IC50 of 
sinomenine in BEL-7402 cells was 5.351 mmol/L, and the IC50 of sinomenine in 
SMMC-7721 cells was 6.204 mmol/L. The gene expression results showed the 
relative expression of FGF2, CCND2, DCN, F3, MMP7, NRG1, HMGB1,
TRIM29, HAS2, EHF, CTGF, PLK2 were down-regulated, and the relative 
expression of VEGF A, CITED2, NUPR1, DDX58, IRF9, NAMPT, MMP1, 
NDRG1, HMGA2, PPARGC1A, IFIT2, PARP9, HEY1, LOX, ETV1, ISG15, 
BACH, CYLD were up-regulated. Moreover, the IPA analysis results suggested 
that IFIT3, IFIT1, OAS1, MX1, IRF9, IFI6, IFITM1, ISG15 were up-regulated in 
BEL-7402 cells treated with sinomenine by activating IFNA2. The findings 
presented in this study may provide a promising method for the prevention and 
treatment of liver cancer.},
DOI = {10.32604/oncologie.2020.012436}
}