@Article{oncologie.2020.012492,
AUTHOR = {Siqiang Tian, Yao Jiang, Ying Wang, Jie Song},
TITLE = {Effects of Dexmedetomidine Combined with Remifentanil Anesthesia and  Propofol Combined with Remifentanil Anesthesia on Perioperative  Inflammatory Response and Pulmonary Function in Patients with Lung  Cancer},
JOURNAL = {Oncologie},
VOLUME = {22},
YEAR = {2020},
NUMBER = {1},
PAGES = {13--21},
URL = {http://www.techscience.com/oncologie/v22n1/39627},
ISSN = {1765-2839},
ABSTRACT = {To explore the effects of dexmedetomidine combined with remifentanil 
anesthesia and propofol combined with remifentanil anesthesia on perioperative 
inflammatory response and pulmonary function in patients with lung cancer. Totally 
128 patients admitted to our hospital for lung cancer surgery were taken as the 
research object of this experiment. Among them, 67 cases were sedated with 
dexmedetomidine combined with remifentanil (Group A), and 61 cases were sedated 
with propofol combined with remifentanil (Group B). The changes of vital signs, 
respiratory interval (RR), blood oxygen saturation (SpO2) and blood sugar before 
and after sedation were recorded. The changes of inflammatory factors TNF-α, IL-
6, IL-10, pulmonary function indexes FEV1, FVC, FEV1/FVC in the two groups at 
24 hours after sedation were observed. Hemodynamic heart rate (HR), mean arterial 
pressure (MAP) and other indexes before and after sedation were observed. VAS 
pain score and MMSE score before and after sedation were compared between the 
two groups. The incidence of adverse reactions after sedation was observed in the 
two groups. The decrease of RR and SpO2 in Group B was more remarkable than 
that in Group A (<i>p</i> < 0.05). The elevation of blood sugar in Group A was lower than 
that in Group B (<i>p</i> < 0.05). Group A had lower levels of TNF-α and IL-6 and higher 
level of IL-10 (<i>p</i> < 0.05), and higher expression of FEV1, FVC and FEV1/FVC when 
compared with Group B (<i>p</i> < 0.05). The decrease of HR and MAP in Group B was 
greater than that in Group A (<i>p</i> < 0.05). VAS score was lower in Group A than Group 
B (<i>p</i> < 0.05), and MMSE score was higher in Group A than Group B (<i>p</i> < 0.05). The 
incidence of adverse reactions in Group A was lower than that in Group B, <i>p</i> < 0.05. 
Compared with propofol, dexmedetomidine combined with remifentanil anesthesia 
is more effective in improving postoperative inflammatory factors and pulmonary 
function of lung cancer patients, which is worthier of recommendation.},
DOI = {10.32604/oncologie.2020.012492}
}