@Article{oncologie.2020.012445,
AUTHOR = {Chuanwei Xu, Renju Ding, Chuanping Xu},
TITLE = {Analysis of the Effects of Different Surgical Procedures for the Treatment of  Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the  Prognostic Factors},
JOURNAL = {Oncologie},
VOLUME = {22},
YEAR = {2020},
NUMBER = {1},
PAGES = {43--51},
URL = {http://www.techscience.com/oncologie/v22n1/39630},
ISSN = {1765-2839},
ABSTRACT = {To analyze the effects of different surgical procedures for the treatment 
of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, 
soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight 
patients with differentiated thyroid cancer were selected and grouped as control 
group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group 
(OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL-
2R expression levels; the incidence of complications; and the differentiated 
thyroid carcinoma (DTC) relapse rate were compared between the two groups. The 
serum IL-17 and SIL-2R levels were lower in the OG than in the CG on the third, 
fifth, and seventh days after the operation, but the IL-35 levels were higher than 
those in the CG (<i>p</i> < 0.05). There were no cases of relapse in the OG, and the DTC 
relapse rate was lower than that of the CG (15.38%) (<i>p</i> < 0.05). The differences in 
age; lesion diameter; serum IL-17, IL-35, and SIL-2R expression levels; AJCC 
thyroid cancer stage; and disease type between DTC relapse and relapse-free 
patients were statistically significant (<i>p</i> < 0.05). Older age; higher IL-17, lower IL-
35, and higher SIL-2R expression levels; higher AJCC thyroid cancer stage; and 
disease type were positively correlated with DTC relapse (<i>p</i> < 0.05). Compared 
with subtotal thyroidectomy, total thyroidectomy for the treatment of thyroid 
cancer has greater advantages in improving immune inflammation and reducing 
the relapse rate. Older age; higher IL-17, lower IL-35, and higher SIL-2R 
expression levels; higher AJCC thyroid cancer stage; and disease type are 
independent risk factors affecting thyroid cancer relapse after surgery. These 
findings can reference the selection of clinical surgery procedures in the treatment 
of thyroid cancer.},
DOI = {10.32604/oncologie.2020.012445}
}