TY - EJOU AU - Xu, Chuanwei AU - Ding, Renju AU - Xu, Chuanping TI - Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors T2 - Oncologie PY - 2020 VL - 22 IS - 1 SN - 1765-2839 AB - To analyze the effects of different surgical procedures for the treatment of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight patients with differentiated thyroid cancer were selected and grouped as control group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group (OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL- 2R expression levels; the incidence of complications; and the differentiated thyroid carcinoma (DTC) relapse rate were compared between the two groups. The serum IL-17 and SIL-2R levels were lower in the OG than in the CG on the third, fifth, and seventh days after the operation, but the IL-35 levels were higher than those in the CG (p < 0.05). There were no cases of relapse in the OG, and the DTC relapse rate was lower than that of the CG (15.38%) (p < 0.05). The differences in age; lesion diameter; serum IL-17, IL-35, and SIL-2R expression levels; AJCC thyroid cancer stage; and disease type between DTC relapse and relapse-free patients were statistically significant (p < 0.05). Older age; higher IL-17, lower IL- 35, and higher SIL-2R expression levels; higher AJCC thyroid cancer stage; and disease type were positively correlated with DTC relapse (p < 0.05). Compared with subtotal thyroidectomy, total thyroidectomy for the treatment of thyroid cancer has greater advantages in improving immune inflammation and reducing the relapse rate. Older age; higher IL-17, lower IL-35, and higher SIL-2R expression levels; higher AJCC thyroid cancer stage; and disease type are independent risk factors affecting thyroid cancer relapse after surgery. These findings can reference the selection of clinical surgery procedures in the treatment of thyroid cancer. KW - Thyroid cancer; SIL-2R; prognostic; IL-17; different surgical procedures; IL-35 DO - 10.32604/oncologie.2020.012445