TY - EJOU
AU - Xu, Chuanwei
AU - Ding, Renju
AU - Xu, Chuanping
TI - Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors
T2 - Oncologie
PY - 2020
VL - 22
IS - 1
SN - 1765-2839
AB - To analyze the effects of different surgical procedures for the treatment
of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35,
soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight
patients with differentiated thyroid cancer were selected and grouped as control
group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group
(OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL-
2R expression levels; the incidence of complications; and the differentiated
thyroid carcinoma (DTC) relapse rate were compared between the two groups. The
serum IL-17 and SIL-2R levels were lower in the OG than in the CG on the third,
fifth, and seventh days after the operation, but the IL-35 levels were higher than
those in the CG (p < 0.05). There were no cases of relapse in the OG, and the DTC
relapse rate was lower than that of the CG (15.38%) (p < 0.05). The differences in
age; lesion diameter; serum IL-17, IL-35, and SIL-2R expression levels; AJCC
thyroid cancer stage; and disease type between DTC relapse and relapse-free
patients were statistically significant (p < 0.05). Older age; higher IL-17, lower IL-
35, and higher SIL-2R expression levels; higher AJCC thyroid cancer stage; and
disease type were positively correlated with DTC relapse (p < 0.05). Compared
with subtotal thyroidectomy, total thyroidectomy for the treatment of thyroid
cancer has greater advantages in improving immune inflammation and reducing
the relapse rate. Older age; higher IL-17, lower IL-35, and higher SIL-2R
expression levels; higher AJCC thyroid cancer stage; and disease type are
independent risk factors affecting thyroid cancer relapse after surgery. These
findings can reference the selection of clinical surgery procedures in the treatment
of thyroid cancer.
KW - Thyroid cancer; SIL-2R; prognostic; IL-17; different surgical procedures; IL-35
DO - 10.32604/oncologie.2020.012445