@Article{oncologie.2020.013707,
AUTHOR = {Neslihan Duzkale, Hikmet Taner Teker},
TITLE = {The Relationship <i>BRCA1/2</i> Genes and Family History in Ovarian Cancers},
JOURNAL = {Oncologie},
VOLUME = {22},
YEAR = {2020},
NUMBER = {2},
PAGES = {65--74},
URL = {http://www.techscience.com/oncologie/v22n2/40106},
ISSN = {1765-2839},
ABSTRACT = {<i>BRCA1/2</i> genes are responsible for the hereditary breast and ovarian 
cancer syndrome. In this study, Turkish women with ovarian cancer were 
investigated in terms of demographic, clinicopathologic and family cancer stories 
according to their condition of the <i>BRCA1/2</i> genes mutation carrier. During 2011 
to 2017 in Turkey, <i>BRCA1</i> and <i>BRCA2</i> genes were analyzed in 38 women, who 
were diagnosed with cancer using Next Generation Sequencing technique.
Pathogenic mutations were detected in 9 (23.7%) of patients. The diagnosis age 
for Ovarian cancer patients for <i>BRCA1/2</i> mutation carriers was found higher. It 
was seen that mutations mostly occurred in the <i>BRCA2</i> gene and frameshift 
mechanism and they were located in exon10 in the <i>BRCA1</i> gene and especially 
in exon11 in the <i>BRCA2</i> gene. According to the applied logistic regression model, 
it was found that patients with more than two relatives having cancer would have 
a 12.844 fold and high risk of being a <i>BRCA1/2</i> mutation carrier. In women with 
ovarian cancer, <i>BRCA1/2</i> gene mutations are observed more frequently in certain 
exons of these genes. <i>BRCA1</i> mutation carriers are diagnosed with ovarian 
cancer earlier than <i>BRCA2</i> mutation carriers. In hereditary ovarian cancers, 
besides <i>BRCA1/2</i>, many identified genes and many modifier candidate genes that 
are waiting to be discovered can cause this condition. In the family history, the 
numerical increase of cancerous relatives significantly increases the risk of 
<i>BRCA1/2</i> carrying mutation.},
DOI = {10.32604/oncologie.2020.013707}
}