@Article{oncologie.2020.012439,
AUTHOR = {Dan Zhang, Shengyong Fu, Jie Xu, Xia Sun},
TITLE = {Clinical Significance of CA-199 and LINC01197 in Pancreatic Cancer},
JOURNAL = {Oncologie},
VOLUME = {22},
YEAR = {2020},
NUMBER = {2},
PAGES = {95--105},
URL = {http://www.techscience.com/oncologie/v22n2/40109},
ISSN = {1765-2839},
ABSTRACT = {This study aimed to explore the expression and clinical significance of 
LINC01197 in the serum of patients with pancreatic cancer (PC). <b>Methods:</b> A 
total of 50 PC patients (patient group) treated in our hospital from March 2012 to 
April 2014 were collected, and another 50 healthy people (normal group) were 
collected for physical examination. The expression of LINC01197 in the serum of 
the two groups was detected by qRT-PCR method, and the expression of CA-199 
in serum was detected by Roche automatic biochemistry. The expression and 
diagnostic values of CA-199 and LINC01197 in PC were analyzed, and the 
relationship between LINC01197 and the prognosis of PC patients was observed. 
<b>Results:</b> The expression of CA-199 in the patient group was significantly higher 
than in the normal group (<i>p</i> < 0.001). The area under the curve was 0.791 and 
0.944, respectively. The incidence rate of Phases III + IV, lymphatic invasion, and 
distant metastasis in patients with low expression of LINC01197 is significantly 
higher than that in patients with high expression and has higher diagnostic value. 
With the progress of clinical staging, the expression of TNM gradually decreased 
and there were differences between groups (<i>p</i> < 0.001). Sperman test analysis 
found that the decreased TNM staging of LINC01197 gradually increased (r = –
0.816, <i>p</i> < 0.001), and the area under the curve of LINC01197 distinguishing phase 
I and phase II + phase III + phase IV was 0.930. The 1-year survival rate and 5-
year survival rate of patients in low expression group are lower than those in the 
high expression group (P1 year = 0.037, P5 year = 0.014). Distant metastasis is an 
independent prognostic factor for PC patients to survive for 1 to 5 years. 
Differentiation, TNM staging, and LINC01197 are independent prognostic factors 
for PC patients to survive for 5 years. <b>Conclusion:</b> The low expression of 
LINC01197 in PC patients indicates poor prognosis of patients and is expected to 
be a potential diagnostic and prognostic indicator of PC.},
DOI = {10.32604/oncologie.2020.012439}
}