@Article{oncologie.2020.014449,
AUTHOR = {Burcu BİTERGE SÜT, Ayşe İKİNCİ KELEŞ},
TITLE = {Prognostic and Predictive Significance of Eukaryotic Elongation Factor 1D  (eEF1D) in Breast Cancer: A Potential Marker of Response to Endocrine  Therapy},
JOURNAL = {Oncologie},
VOLUME = {22},
YEAR = {2020},
NUMBER = {3},
PAGES = {147--154},
URL = {http://www.techscience.com/oncologie/v22n3/40579},
ISSN = {1765-2839},
ABSTRACT = {Components of the protein synthesis machinery are subjected to 
alterations in cancer cells. eEF1D gene, which lies within the frequently amplified 
8q24 locus, is one of the subunits of the human eukaryotic elongation factor 
complex. This study aimed to evaluate the prognostic and predictive significance 
of eEF1D in breast cancer using in silico analysis tools. For this purpose, we 
analyzed genomic alterations of the eEF1D gene using TCGA datasets via 
cBioPortal. Histopathological analysis was performed on patient tissue images 
obtained from cBioPortal and the Human Protein Atlas. Survival analysis was 
carried out using the KM Plotter and the prediction of response to therapy was 
assessed via the ROC Plotter. We found that eEF1D was highly amplified and 
overexpressed in breast invasive carcinoma. Increased expression of eEF1D was 
correlated with increased structural disorganization and morphological alterations 
at the cellular level, as well as a shorter period of overall survival. Furthermore, 
prediction of response to therapy showed that patients with eEF1D overexpression 
responded significantly better to endocrine therapy. In conclusion, our results 
suggest a cancer-promoting role for eEF1D, associated with poor prognosis and 
points towards its predictive value in providing better tailored treatment options 
for a patient.},
DOI = {10.32604/oncologie.2020.014449}
}