@Article{oncologie.2020.012495,
AUTHOR = {Li Bao, Xiaowei Tian, Jing Zhang, Li Chen, Kui Gao},
TITLE = {Effects of Ulinastatin Combined with Dexmedetomidine on Postoperative  Cognitive Function and Central Nerve Specific Protein Level in Elderly  Colorectal Cancer Patients after Laparoscopic},
JOURNAL = {Oncologie},
VOLUME = {22},
YEAR = {2020},
NUMBER = {3},
PAGES = {167--178},
URL = {http://www.techscience.com/oncologie/v22n3/40582},
ISSN = {1765-2839},
ABSTRACT = {Ulinastatin combined with dexmedetomidine can improve 
postoperative cognitive function and central nerve specific protein (S-100β) level 
in elderly colorectal cancer (CC) patients after laparoscopic. Altogether 178 
elderly patients who underwent laparoscopic colorectal cancer surgery in our 
hospital from February 2018 to August 2019 were selected and divided into two 
groups according to the treatment methods. Those anesthetized by 
dexmedetomidine were regarded as the routine group (RG, 83 cases), and those 
anesthetized by ulinastatin and dexmedetomidine were considered as the 
combined group (CG, 95 cases). The operation conditions of the two groups, the 
pain scores (VAS) at 4 h, 24 h and 48 h after surgery, and the MMSE scores before, 
1 d and 3 d after surgery were recorded. The incidence of cognitive dysfunction 
and adverse reactions were compared between both groups. The serum S-100β 
protein (S-100β) and inflammatory factors were detected by enzyme-linked 
immunosorbent assay (ELISA). The risk factors of postoperative cognitive 
dysfunction (POCD) were analyzed. The eye-opening time of clinical indexes in 
the CG was dramatically lower than in the RG, while other indexes had no marked 
difference. The VAS scores of the CG were lower than those of the RG at 4 h, 24 
h and 48 h after operation. The MMSE scores of patients in the CG were 
dramatically higher than those in the RG at 1 d and 3 d after surgery. The total 
incidence of POCD in the CG was lower than that in the RG. There was no 
remarkable difference in the total incidence of adverse reactions between both 
groups. The S-100β expression level in the CG was dramatically lower than in the 
RG at 1 d and 3 d after surgery. The improvement level of inflammatory factors 
in the CG was dramatically better than that in the RG. Multivariate Logistic 
regression analysis identified that the eye-opening time, VAS score, IL-10, TNF-
α, CRP, and S-100β were independent risk factors for POCD occurrence in elderly 
CC patients after surgery. Ulinastatin combined with dexmedetomidine anesthesia 
induction can improve the prognosis of elderly CC patients after laparoscopic and 
it also reduces postoperative pain and serum inflammatory factors. S-100β 
concentration can improve the POCD occurrence after surgery.},
DOI = {10.32604/oncologie.2020.012495}
}