@Article{oncologie.2021.014152,
AUTHOR = {Xin Chang, Jin Wang, Caifang Ni},
TITLE = {Value of Mir-1271 and GPC3 in Prognosis Evaluation of Liver Cancer Patients after Liver Transarterial Chemoembolization},
JOURNAL = {Oncologie},
VOLUME = {23},
YEAR = {2021},
NUMBER = {1},
PAGES = {119--130},
URL = {http://www.techscience.com/oncologie/v23n1/41906},
ISSN = {1765-2839},
ABSTRACT = {<b>Objective:</b> This research was designed to observe the value of miR-1271 and GPC3 in evaluating the prognosis of liver cancer (LC) patients after liver transarterial chemoembolization (TACE). <b>Methods:</b> A total of 80 patients diagnosed as LC in our hospital from January 2018 to April 2019 were included in the LC group (LCG), and then assigned into a survival group (SG) and a death group (DG) based on prognosis. Seventy healthy subjects undergoing physical examination simultaneously were included in the normal group (NG). miR-1271 and GPC3 in serum of two groups of subjects were tested via qRT-PCR. ROC curve was drawn. The prognostic factors were assessed via multivariate Cox regression analysis. <b>Results:</b> The expression of miR-1271 in the LCG was notably lower than the NG, while GPC3 expression in the LCG was notably higher (<i>P</i> < 0.001). Patients with low miR-1271 expression and high GPC3 expression had a higher incidence of low differentiation, grade III+IV, lymphatic invasion and distant metastasis (<i>P</i> < 0.05). Both AUC of miR-1271 and GPC3 single diagnosis were higher than 0.8. The relative expression of serum miR-1271 in the SG was markedly higher than the DG, while that of serum GPC3 in the SG was markedly lower (both <i>P</i> < 0.001). ROC was drawn. The AUC of serum miR-1271 and GPC3 in diagnosing prognosis were higher than 0.8, and there was no marked difference in sensitivity and specificity. Cox regression analysis was performed on 5-year survival, and the results manifested that miR-1271 was an independent factor affecting prognosis. <b>Conclusion:</b> miR-1271 and GPC3 may be implicated in LC development and metastasis, and can be employed as potential serum biomarkers for post-TACE evaluation.},
DOI = {10.32604/oncologie.2021.014152}
}