@Article{Oncologie.2021.014790,
AUTHOR = {Xiaolin Wu, Lanping Diao, Guimin Zhao, Chen Huang, Yingzhen Yao, Zhe Gao, Lili Wu},
TITLE = {The mtDNA Microsatellite Instability Indicated the Prognosis of Chinese Patients with Non-Hodgkin’s Lymphoma},
JOURNAL = {Oncologie},
VOLUME = {23},
YEAR = {2021},
NUMBER = {1},
PAGES = {141--148},
URL = {http://www.techscience.com/oncologie/v23n1/41909},
ISSN = {1765-2839},
ABSTRACT = {This study aimed to investigate the relationship and diagnostic potential between microsatellite instability (MSI) caused by a 9-bp GGGGGTAGA insertion/deletion in mitochondrial DNA (mtDNA) at position 8272 and clinical features in Chinese patients diagnosed with non-Hodgkin’s lymphoma. The 9-bp GGGGGTAGA insertion/deletion in the non-d-loop area of the mitochondrial DNA at the 8272 locus was detected by PCR in 139 non-Hodgkin’s lymphoma patient samples. GGGGGTAGA insertion/deletion was found in a total of 16 cases (11.5%), including nine T cell lymphoma and seven B cell lymphoma cases. The 5-year survival rate was 33.3% in patients with non-Hodgkin’s lymphoma and MSI, and was 26.7% in non-Hodgkin’s lymphoma patients lacking MSI. In B-cell lymphoma, the 5-year survival rate was 42.9% in patients harboring the 9-bp insertion/deletion, and was 36.8% in patients lacking MSI. In T-cell lymphoma, the 5-year survival rate was 55.6% in patients with the 9-bp insertion/deletion, and was 16.4% in patients lacking MSI (<i>p</i> < 0.05). The difference between 5-year survival rates was statistically significant only in T-cell lymphoma patients. In conclusion, the mtDNA GGGGGTAGA indel/variation at position 8272 can be used as an independent prognostic marker for T-cell lymphoma.},
DOI = {10.32604/Oncologie.2021.014790}
}