TY  - EJOU
AU  - Wu, Xiaolin 
AU  - Diao, Lanping 
AU  - Zhao, Guimin 
AU  - Huang, Chen 
AU  - Yao, Yingzhen 
AU  - Gao, Zhe 
AU  - Wu, Lili 

TI  - The mtDNA Microsatellite Instability Indicated the Prognosis of Chinese Patients with Non-Hodgkin’s Lymphoma
T2  - Oncologie

PY  - 2021
VL  - 23
IS  - 1
SN  - 1765-2839

AB  - This study aimed to investigate the relationship and diagnostic potential between microsatellite instability (MSI) caused by a 9-bp GGGGGTAGA insertion/deletion in mitochondrial DNA (mtDNA) at position 8272 and clinical features in Chinese patients diagnosed with non-Hodgkin’s lymphoma. The 9-bp GGGGGTAGA insertion/deletion in the non-d-loop area of the mitochondrial DNA at the 8272 locus was detected by PCR in 139 non-Hodgkin’s lymphoma patient samples. GGGGGTAGA insertion/deletion was found in a total of 16 cases (11.5%), including nine T cell lymphoma and seven B cell lymphoma cases. The 5-year survival rate was 33.3% in patients with non-Hodgkin’s lymphoma and MSI, and was 26.7% in non-Hodgkin’s lymphoma patients lacking MSI. In B-cell lymphoma, the 5-year survival rate was 42.9% in patients harboring the 9-bp insertion/deletion, and was 36.8% in patients lacking MSI. In T-cell lymphoma, the 5-year survival rate was 55.6% in patients with the 9-bp insertion/deletion, and was 16.4% in patients lacking MSI (<i>p</i> < 0.05). The difference between 5-year survival rates was statistically significant only in T-cell lymphoma patients. In conclusion, the mtDNA GGGGGTAGA indel/variation at position 8272 can be used as an independent prognostic marker for T-cell lymphoma.
KW  - Mitochondrial microsatellite instability; non-Hodgkin’s lymphoma; prognosis

DO  - 10.32604/Oncologie.2021.014790