TY  - EJOU
AU  - Ren, Weifeng 
AU  - Cai, Xiaomeng 
AU  - Chen, Jun 
AU  - Ruan, Lifo 
AU  - Lu, Huiru 
AU  - Zhang, Jiayu 
AU  - Hu, Yi 
AU  - Gao, Jimin 

TI  - GM-CSF-Loaded Nanoparticles for Photothermal-Assisted Immunotherapy against Orthotopic Bladder Cancer
T2  - Oncologie

PY  - 2021
VL  - 23
IS  - 3
SN  - 1765-2839

AB  - This study reported the construction of GM-CSF-loaded chitosan/graphene oxide nanoparticles for photothermal therapy-assisted immunotherapy against murine orthotopic bladder cancer. The encapsulated GM-CSF in chitosan/graphene oxide nanoparticles facilitated their immobilization on biotinylated mouse orthotopic bladder cancer surface, resulting in slow release of antitumor immune adjuvant. Locally released GM-CSF efficiently recruited dendritic cells to bladder tumor sites, thereby promoting immune responses in mice. Thus, the activated immune response in mice provided enhanced antitumor effects. Meanwhile, the thermal effect from the nanoparticles upon light irradiation induced a significant increase in dendritic cells and T cells compared with other groups, which confirmed that the focal photothermal effect potentiated antitumor immune response to tumors.
KW  - Nanoparticles; SA-mGM-CSF; bladder cancer; immunotherapy; photothermal therapy

DO  - 10.32604/Oncologie.2021.018605