TY  - EJOU
AU  - Zhu, Xingyu 
AU  - Wang, Yongjun 
AU  - Chang, Shuang 
AU  - Su, Yue 
AU  - He, Cuixia 
AU  - Hu, Shuang 
AU  - Zhu, Minhui 
AU  - Ding, Yuzhou 
AU  - Ren, Nuannuan 
AU  - Wang, Qizhi 
AU  - Xie, Jing 
AU  - Zhou, Huan 

TI  - Epigenetics of Sirtuins: Relevance to Hepatocellular Carcinoma
T2  - Oncologie

PY  - 2021
VL  - 23
IS  - 4
SN  - 1765-2839

AB  - Sirtuins (SIRTs), members of the enzyme family found in yeast cells, are related to silent information regulator
(SIR) 2 homologous to its gene family. SIRTs play an important role in many physiological functions from overexpression of gene silencing at the molecular level to the expression of related proteins and RNA to apoptosis.
Studies have indicated that SIRTs may be related to the occurrence, development, and metastasis of cancer. However, the current mechanism of action of SIRTs in various diseases and the principle of molecular biology are not
fully understood. Therefore, the present article discusses the main regulatory role and function of SIRTs in HCC
and evaluates SIRTs as new targets for HCC treatment.
KW  - Sirtuins (SIRTs); hepatocellular carcinoma (HCC); deacetylation; microRNA (miRNA); methylation

DO  - 10.32604/oncologie.2021.018869