TY - EJOU AU - Zhao, Ping AU - Xu, Yao AU - Wu, Anqi AU - Hu, Yuhao AU - Cai, Aiting AU - Wang, Xinyue AU - Wang, Feng AU - Chen, Xiang TI - Circular RNA hsa_circ_0016863 Regulates the Proliferation, Migration, Invasion and Apoptosis of Hepatocellular Carcinoma T2 - Oncologie PY - 2021 VL - 23 IS - 4 SN - 1765-2839 AB - Background: Although there has been a part of research that the expression of circular RNAs (circRNAs) is bound up with the occurrence, development and prognosis of multiple tumors, what roles circRNAs have in hepatocellular carcinoma (HCC) remain to be explored. Methods: Hsa_circ_0016863 showed a trend of high expression in HCC tissues by Microarray GSE97332. The expression of hsa_circ_0016863 in HCC and adjacent non-cancerous tissues was detected by qRT-PCR. The role of hsa_circ_0016863 in HCC was investigated by colony formation assay, cell proliferation assay, Transwell assay and flow cytometry. Results: Hsa_circ_0016863 exhibited a trend of high expression in HCC. Cell experiments showed that upregulated hsa_circ_0016863 promoted HCC cell proliferation, migration and invasion, whereas it inhibited cell apoptosis, while silencing hsa_circ_0016863 showed the opposite results. Conclusions: Hsa_circ_0016863 shows a trend of high expression in HCC, which may be related to the development of HCC. KW - Proliferation; migration; invasion; apoptosis; HCC; hsa_circ_0016863 DO - 10.32604/oncologie.2021.018713