@Article{oncologie.2021.019519,
AUTHOR = {Dang Quang Hung, Nguyen-Thi Nhan, Trinh-Thi Phuong Nga, Nguyen Thanh Hai, Nguyen Quang Duc, Nguyen Viet Thu, Nguyen Truong Duc, Dinh-Van Thuyet, Nguyen Minh Duc},
TITLE = {A Rare Case of Atraumatic Splenic Rupture Due to Metastatic Hepatocellular Carcinoma},
JOURNAL = {Oncologie},
VOLUME = {23},
YEAR = {2021},
NUMBER = {4},
PAGES = {603--608},
URL = {http://www.techscience.com/oncologie/v23n4/46103},
ISSN = {1765-2839},
ABSTRACT = {Metastatic spread of hepatocellular carcinoma (HCC) to the spleen is uncommon, only occurring in approximately 1% of cases. Atraumatic splenic rupture due to HCC metastasis is extremely rare and affects patient prognosis, clinical management, and mortality. We report a case of a 65-year-old man with a history of chronic
hepatitis B infection who presented with left-sided abdominal pain and fatigue. Clinical examination showed
acute anemia with elevated levels of serum alpha-fetoprotein (AFP) and protein induced by vitamin K absence
(PIVKA-II). On ultrasound and computed tomography imaging, hemoperitoneum caused by a ruptured splenic
tumor was revealed. In addition to multiple hepatic lesions, enlarged abdominal lymph nodes and osteolytic
lesions in the thoracic vertebral bodies were detected. The patient underwent total splenectomy and was diagnosed histopathologically with splenic rupture secondary to Grade 2 HCC metastasis. Atraumatic, pathological
splenic rupture due to HCC metastasis should be considered in patients with chronic hepatitis B or C infection
and increasing serum AFP and PIVKA-II levels, even though splenic metastasis is uncommon.},
DOI = {10.32604/oncologie.2021.019519}
}