TY - EJOU AU - Meng, Xingjun AU - Cao, Zhihui AU - Liu, Renfeng AU - Zheng, Kai AU - Ding, Shuai AU - Gu, Yuefan AU - Chen, Yonghua AU - Lv, Jun AU - Li, Ping AU - Zhou, Li AU - Wang, Wenbo AU - Ji, Shiliang AU - He, Hui AU - Yang, Hui TI - Paclitaxel Combined with Ticagrelor Inhibits B16F10 and Lewis Lung Carcinoma Cell Metastasis T2 - Oncologie PY - 2022 VL - 24 IS - 2 SN - 1765-2839 AB - It is widely accepted that tumor metastasis is the dominant factor leading to cancer-related death. Tumor metastasis is mediated by cell invasion, blood circulation and lymphatic circulation. Paclitaxel, as a common anti-tumor drug and a mitotic inhibitor, promotes microtubule assembly and inhibits microtubule depolymerization. In addition, ticagrelor, an anti-platelet drug, is used to treat acute coronary syndrome. Increasing numbers of studies have reported that platelets can facilitate tumor metastasis. Therefore, inhibiting the effects of platelets can serve as a novel therapeutic strategy for cancer. To explore the effect of anti-tumor and anti-platelet drugs on tumor progression, we chose paclitaxel and ticagrelor. Interestingly, the results demonstrated that paclitaxel and ticagrelor could not only suppress the proliferation, migration and invasion of B16F10 and LLC cells, but they could also prevent tumor metastasis to the lungs. Furthermore, the inhibitory effect of paclitaxel and ticagrelor was more apparent when both drugs were used in combination. Collectively, the current study demonstrated that the combination of paclitaxel and ticagrelor could be considered as a potential anti-tumor therapy approach. KW - Paclitaxel; ticagrelor; tumor metastasis; B16F10; Lewis lung carcinoma DO - 10.32604/oncologie.2022.021259