@Article{oncologie.2022.022454,
AUTHOR = {Lipeng Gao, Rongyin Gui, Xinnan Zheng, Yingxue Wang, Yao Gong, Tim Hua Wang, Jichuang Wang, Junyi Huang, Xinhua Liao},
TITLE = {Topical Application of <i>Houttuynia cordata Thunb</i> Ethanol Extracts Increases Tumor Infiltrating CD<sup>8+</sup> /Treg Cells Ratio and Inhibits Cutaneous Squamous Cell Carcinoma <i>in vivo</i>},
JOURNAL = {Oncologie},
VOLUME = {24},
YEAR = {2022},
NUMBER = {3},
PAGES = {565--577},
URL = {http://www.techscience.com/oncologie/v24n3/49713},
ISSN = {1765-2839},
ABSTRACT = {<i>Houttuynia cordata Thunb</i> (HCT) is a medicinal and edible herb that has beneficial effects on various diseases due
to its diuretic, anti-inflammatory, anti-oxidative, anti-microbial, anti-viral, anti-cancer and anti-diabetic properties. Most reports of its anti-cancer activity were conducted in vitro, and its effects on cutaneous squamous cell
carcinoma (SCC) have not been investigated yet. Using DMBA/TPA induced SCC mice model, we found that
topical treatment by HCT, as well as its bioactive ingredient monomer, efficiently inhibited tumor growth.
Mechanistically, tumor infiltrating CD<sup>4+</sup>
, Foxp<sup>3+</sup> T regulatory cells (Tregs) were significantly reduced and
CD<sup>8+</sup>
/Treg cells ratio was largely increased in tumors after HCT treatment. In addition, several chemokines
which function to recruit immune cells were largely reduced in SCC cancer cells treated by HCT <i>in vitro</i>. Our
results demonstrate the therapeutic effects of HCT on cutaneous SCC and indicate it might inhibit cancer through
regulating tumor infiltrating lymphocytes and the tumor immune microenvironments.},
DOI = {10.32604/oncologie.2022.022454}
}