@Article{oncologie.2022.025144,
AUTHOR = {Sen Lu, Zunqiang Zhao, Zhongwei Lv, Jianshe Yang},
TITLE = {A Novel Biological Nano Confinement Inhibits Cancer Metastasis},
JOURNAL = {Oncologie},
VOLUME = {24},
YEAR = {2022},
NUMBER = {3},
PAGES = {591--597},
URL = {http://www.techscience.com/oncologie/v24n3/49714},
ISSN = {1765-2839},
ABSTRACT = {Cancer is a complex genetic disease hallmarked with a strong competitive capacity in energy and utilization of
substances compared to normal cells, which is partially due to the ability to adjust their metabolism in response
to environmental changes. During the lifespan of cancer cells, either during carcinogenesis, progress, or metastasis, massive energy and other substances are essential prerequisites, however, the underlying mechanisms are
controversial and still remain unclear. Understanding how cancer cells seize much of the energy and other substances than normal cells is of utmost importance for next-generation cancer therapy, along with the finding of
novel drug target and drug design. Recent reports about ‘mitochondrial hijack’ of cancer cells through selfassembled protein nanotubes connected with normal cells and ‘graded messengers pool’ in cytoplasm have evoked
a great interest. Considering the widely discussed ‘nanodomain’ in physical and chemical areas, we proposed the
concept of biological nano confinement (BNC), by which we may rationally elucidate the priorities of solid
tumors on utilization of energy and substances at hypoxia, and less nutrition supplying environments both extraand intra-cellular. The ultimate objective was to address the confusion that CAR-T therapies are effective for
hematological cancers but less effective for solid tumors and also to reveal the fact that chimeric antigens receptor-T (CAR-T) adjuvant therapy with chemotherapy has synergetic enhancement effects. In turn, developing
novel inhibitors to depolymerize biological nanoconfinement is urgently needed.},
DOI = {10.32604/oncologie.2022.025144}
}