@Article{oncologie.2022.023248,
AUTHOR = {Xin Shu, Qiang Wang, Qingming Wu},
TITLE = {The Eph/Ephrin System in Hepatocellular Carcinoma: Functional Roles and Potential Therapeutic Targets},
JOURNAL = {Oncologie},
VOLUME = {24},
YEAR = {2022},
NUMBER = {3},
PAGES = {427--439},
URL = {http://www.techscience.com/oncologie/v24n3/49720},
ISSN = {1765-2839},
ABSTRACT = {Liver cancer is ranked as the second leading cause of cancer-related death across the world, and hepatocellular
carcinoma (HCC) comprises nearly 90% of all primary liver cancer cases. However, until now, the pathological
mechanisms underlying HCC oncogenesis and development remains largely unclear. Eph receptors and their
ephrin ligands (Eph/Ephrin system) are involved in various physiological process, such as embryogenesis, neuronal migration, immune response and vascular development. Recently, emerging evidence has showed that the
Eph/Ephrin system also plays an essential role in initiation and development of multiple types of cancer, including
liver cancer. The Eph/Ephrin system has been reported to contribute to cellular proliferation, apoptosis, migration, invasion, angiogenesis, stemness and drug/radiotherapy resistance in HCC. Thus, the aim of this review is to
summarize the effects and underlying mechanisms of every member of this system in HCC, with special focus on
assessing their therapeutic potential as drug targets.},
DOI = {10.32604/oncologie.2022.023248}
}