@Article{096504015X14410238486649,
AUTHOR = {Fei Meng, Wei Liu},
TITLE = {Knockdown of Legumain Suppresses Cervical Cancer Cell Migration and Invasion},
JOURNAL = {Oncology Research},
VOLUME = {23},
YEAR = {2015},
NUMBER = {1-2},
PAGES = {7--12},
URL = {http://www.techscience.com/or/v23n1-2/57564},
ISSN = {1555-3906},
ABSTRACT = {Cervical cancer is the second leading type of cancer in women living in less developed countries. The pathological and molecular mechanisms of cervical cancer are not comprehensively known. Though legumain has 
been found to be highly expressed in various types of solid tumors, its expression and biological function in 
cervical cancer remain unknown. In this study, we aimed to investigate legumain expression and functions in 
cervical cancer. We found that legumain was highly expressed in cervical cancer cells. When knocked down, 
legumain expression in HeLa and SiHa cells significantly reduced its migration and invasion abilities compared with control cells. Furthermore, legumain silencing suppressed the activation of matrix metalloproteases 
(MMP2 and MMP3) in cervical cancer cells. This study indicates that legumain might play an important role 
in cervical cancer cell migration and invasion. Legumain might be a potential therapeutic target for cervical 
cancer therapy.},
DOI = {10.3727/096504015X14410238486649}
}