@Article{096504015X14452563486011,
AUTHOR = {Xiang Zhou, Weiming Wang, Pihong Li, Zhiqiang Zheng, Yangyang Tu, Yi Zhang, Tao You},
TITLE = {Curcumin Enhances the Effects of 5-Fluorouracil and Oxaliplatin in Inducing  Gastric Cancer Cell Apoptosis Both In Vitro and In Vivo},
JOURNAL = {Oncology Research},
VOLUME = {23},
YEAR = {2015},
NUMBER = {1-2},
PAGES = {29--34},
URL = {http://www.techscience.com/or/v23n1-2/57567},
ISSN = {1555-3906},
ABSTRACT = {Despite the efficacy of fluoropyrimidines and oxaliplatin-based chemotherapy for patients, this treatment leads to 
significant patient inconvenience, toxicity, and cost. This study aims to validate a nontoxic agent, curcumin, to 
the current chemotherapeutic regimen. In in vitro experiments, curcumin induced apoptosis in gastric cancer cell 
line BGC-823. Synergistic antitumor effects of curcumin were observed in combination with 5-fluorouracil (5-FU) 
and oxaliplatin. These effects were accompanied by downregulation of the expression of Bcl-2 protein and mRNA 
and upregulation of the expression of Bax and caspase 3, 8, and 9. In addition, the in vivo study showed that the 
combination of curcumin and 5-FU/oxaliplatin exhibited potent growth inhibition of BGC-823 xenograft tumors. 
Furthermore, compared with the control group, no significant difference was observed in the body weight of curcumintreated nude mice. In conclusion, curcumin may act synergistically with the chemotherapeutic regimen FOLFOX in 
gastric cancer in vitro and in vivo by inducing apoptosis via Bcl/Bax–caspase 8,9–caspase 3 pathway.},
DOI = {10.3727/096504015X14452563486011}
}