@Article{096504016X14514194509664,
AUTHOR = {Akinobu Furutani, Yoshihiro Sowa, Hitoshi Fujiwara, Eigo Otsuji, Toshiyuki Sakai},
TITLE = {The Novel HDAC Inhibitor OBP-801/YM753 Enhances the Effects of  5-Fluorouracil With Radiation on Esophageal Squamous Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {23},
YEAR = {2015},
NUMBER = {1-2},
PAGES = {87--87},
URL = {http://www.techscience.com/or/v23n1-2/57574},
ISSN = {1555-3906},
ABSTRACT = {Histone deacetylase (HDAC) inhibitors have been shown to enhance the effects of 5-fluorouracil (5-FU) 
against various cancer cells; however, no report has shown that an HDAC inhibitor may enhance the effects of 
5-FU with radiation. Therefore, we investigated whether the novel HDAC inhibitor OBP-801/YM753 could 
enhance the effects of 5-FU with radiation on esophageal squamous carcinoma KYSE170 cells. The inhibition 
of the cell growth was significantly stronger with the combination of OBP-801/YM753 with 5-FU than with 
the 5-FU treatment only. Furthermore, inhibition of the colony formation was the most effective with the combined treatment of OBP-801/YM753, 5-FU, and radiation. Western blot analysis showed that OBP-801/YM753 
suppressed the expression of thymidylate synthase induced by 5-FU. Therefore, this three-combined therapy is 
promising for patients with esophageal squamous carcinoma.},
DOI = {10.3727/096504016X14514194509664}
}