TY  - EJOU
AU  - Furutani, Akinobu 
AU  - Sowa, Yoshihiro 
AU  - Fujiwara, Hitoshi 
AU  - Otsuji, Eigo 
AU  - Sakai, Toshiyuki 

TI  - The Novel HDAC Inhibitor OBP-801/YM753 Enhances the Effects of  5-Fluorouracil With Radiation on Esophageal Squamous Carcinoma Cells
T2  - Oncology Research

PY  - 2015
VL  - 23
IS  - 1-2
SN  - 1555-3906

AB  - Histone deacetylase (HDAC) inhibitors have been shown to enhance the effects of 5-fluorouracil (5-FU) 
against various cancer cells; however, no report has shown that an HDAC inhibitor may enhance the effects of 
5-FU with radiation. Therefore, we investigated whether the novel HDAC inhibitor OBP-801/YM753 could 
enhance the effects of 5-FU with radiation on esophageal squamous carcinoma KYSE170 cells. The inhibition 
of the cell growth was significantly stronger with the combination of OBP-801/YM753 with 5-FU than with 
the 5-FU treatment only. Furthermore, inhibition of the colony formation was the most effective with the combined treatment of OBP-801/YM753, 5-FU, and radiation. Western blot analysis showed that OBP-801/YM753 
suppressed the expression of thymidylate synthase induced by 5-FU. Therefore, this three-combined therapy is 
promising for patients with esophageal squamous carcinoma.
KW  - 5-Fluorouracil (5-FU); Radiation; Histone deacetylase (HDAC) inhibitor; Esophageal squamous carcinoma

DO  - 10.3727/096504016X14514194509664