@Article{096504015X14496932933539,
AUTHOR = {Si Jun Park, Bo Ram Lee, Hyeng-Soo Kim, Young Rae Ji, Yong Hun Sung, Kwang ShikChoi, Hum Dai Park, Sung-Hyun Kim, Myoung Ok Kim, Zae Young Ryoo},
TITLE = {Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells},
JOURNAL = {Oncology Research},
VOLUME = {23},
YEAR = {2015},
NUMBER = {3},
PAGES = {89--98},
URL = {http://www.techscience.com/or/v23n3/57557},
ISSN = {1555-3906},
ABSTRACT = {In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of 
adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced 
ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was 
found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial 
marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings 
suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion 
and epithelial–mesenchymal transition (EMT).},
DOI = {10.3727/096504015X14496932933539}
}