TY  - EJOU
AU  - Park, Si Jun 
AU  - Lee, Bo Ram 
AU  - Kim, Hyeng-Soo 
AU  - Ji, Young Rae 
AU  - Sung, Yong Hun 
AU  - ShikChoi, Kwang 
AU  - Park, Hum Dai 
AU  - Kim, Sung-Hyun 
AU  - Kim, Myoung Ok 
AU  - Ryoo, Zae Young 

TI  - Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells
T2  - Oncology Research

PY  - 2015
VL  - 23
IS  - 3
SN  - 1555-3906

AB  - In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of 
adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced 
ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was 
found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial 
marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings 
suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion 
and epithelial–mesenchymal transition (EMT).
KW  - Tet1; Demethylation; Lung cancer; Epithelial–mesenchymal transition (EMT); Metastasis

DO  - 10.3727/096504015X14496932933539