@Article{096504015X14496932933575,
AUTHOR = {Gao Liu, Tian Xiang, Quan-Feng Wu, Wei-Xing Wang},
TITLE = {Long Noncoding RNA H19-Derived miR-675 Enhances Proliferation and  Invasion via RUNX1 in Gastric Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {23},
YEAR = {2015},
NUMBER = {3},
PAGES = {99--107},
URL = {http://www.techscience.com/or/v23n3/57558},
ISSN = {1555-3906},
ABSTRACT = {The lncRNA H19 and its mature product miR-675 have recently been shown to be upregulated and promote the 
progression of gastric cancer. However, the detailed function and underlying molecular mechanism of H19/miR-
675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that H19 depended on miR-
675 to enhance the proliferation and invasion of gastric cancer AGS cells, and the expression of miR-675 was 
positively correlated with H19 in patients with gastric cancer. Subsequently, the tumor-suppressor runt domain 
transcription factor 1 (RUNX1) was confirmed to be a downstream molecule of H19/miR-675 axis, since overexpression of H19 or miR-675 significantly decreased RUNX1 expression in AGS cells, and knockdown of 
H19 or miR-675 enhanced RUNX1 expression. More importantly, a series of assays further demonstrated that 
introduction of RUNX1 abrogated H19/miR-675-induced Akt/mTOR pathway activation and the following cellular proliferation and invasion of AGS cells. To our knowledge, this is the time to demonstrate that RUNX1 
serves as a link between H19/miR-675 axis and Akt/mTOR signaling and is a pivotal mediator in gastric cancer 
progression induced by H19/miR-675. Thus, our study provides important clues for understanding the key roles 
of lncRNA-miRNA functional network and identifying new therapeutic targets for gastric cancer.},
DOI = {10.3727/096504015X14496932933575}
}