@Article{096504016X14519157902726,
AUTHOR = {Pengwei Lu, Yuanting Gu, Lin Li, Fang Wang, Xinguang Qiu},
TITLE = {miR-544a Promotes Breast Cancer Cell Migration and Invasion Reducing Cadherin 1 Expression},
JOURNAL = {Oncology Research},
VOLUME = {23},
YEAR = {2015},
NUMBER = {4},
PAGES = {165--170},
URL = {http://www.techscience.com/or/v23n4/57553},
ISSN = {1555-3906},
ABSTRACT = {Accumulating evidence has reported the significant role of miRNAs in the underlying biology of tumors, 
including breast cancer. The purpose for this study was to investigate the potential effects of miR-544a in 
breast cancer migration and invasion. The human normal breast Hs578Bst cells and the human breast cancer 
MCF-7 and MDA-MB-231 cells were used to analyze the expression of miR-544a by RT-PCR. The effects of 
miR-544a on the two kinds of breast cancer cell migration and invasion were analyzed using the Matrigel and 
Transwell assay, respectively. miR-544a expression on the cell metastasis-related protein expression was also 
analyzed using Western blotting. Compared to the normal Hs578Bst cells, miR-544a was significantly downregulated in MCF-7 cells but was upregulated in MDA-MB-231 cells (<i>p</i><0.01). The overexpressed miR-544a 
significantly promotes the migrated and invaded MCF-7 cells (<i>p</i><0.05), which was opposite to that in MCAMB-231 cells (<i>p</i><0.05). Moreover, the cadherin 1 (CDH1) expression was negatively correlated to miR-544a 
expression in the two kinds of cells. Our study suggested that the overexpressed miR-544a may be a promoter 
for breast cancer migration and invasion by targeting CDH1.},
DOI = {10.3727/096504016X14519157902726}
}