@Article{096504016X14562725373716,
AUTHOR = {Hongtao Ren, Zhongwei Wang, Shuqun Zhang, Hongbing Ma, Yali Wang, Lijun Jia, Yiming Li},
TITLE = {IL-17A Promotes the Migration and Invasiveness of Colorectal Cancer Cells Through NF-kB-Mediated MMP Exp},
JOURNAL = {Oncology Research},
VOLUME = {23},
YEAR = {2015},
NUMBER = {5},
PAGES = {249--256},
URL = {http://www.techscience.com/or/v23n5/57549},
ISSN = {1555-3906},
ABSTRACT = {Interleukin-17A (IL-17A) plays a significant role in many inflammatory diseases and cancers. The aim of this 
study is to investigate the effect of IL-17A on the invasiveness of colorectal cancer. In the study, we found that 
IL-17A could promote the migration and invasion of colorectal cancer cells. Furthermore, after being treated 
with IL-17A, the expression and activity of matrix metalloproteinase 2 (MMP-2) and MMP-9 were upregulated. 
Moreover, the nuclear/overall fractions and DNA-binding activity of p65 and p50 were dramatically elevated by 
IL-17A. Pretreatment with a nuclear factor-kB (NF-kB) inhibitor (PDTC) or PI3K/AKT inhibitor (LY294002) 
was proven to abolish the promoting effect of IL-17A on the invasion ability of colorectal cancer cells and upregulation of MMP-2/9. In conclusion, our findings demonstrated that IL-17A could promote the invasion of colorectal 
cancer cells by activating the PI3K/AKT/NF-kB signaling pathway and subsequently upregulating the expression 
of MMP-2/9. Our results suggest that IL-17A could serve as a promising therapeutic target for colorectal cancer.},
DOI = {10.3727/096504016X14562725373716}
}