TY  - EJOU
AU  - Lu, Meng 
AU  - Miao, Yi 
AU  - Qi, Lan 
AU  - Bai, Mingzhu 
AU  - Zhang, Jiarong 
AU  - Feng, Youji 

TI  - RNAi-Mediated Downregulation of FKBP14 Suppresses the Growth of Human Ovarian Cancer Cells
T2  - Oncology Research

PY  - 2015
VL  - 23
IS  - 6
SN  - 1555-3906

AB  - FKBP14 belongs to the family of FK506-binding proteins (FKBPs). Altered expression of FKBPs has been 
reported in several malignancies. This study aimed to reveal the expression profile of FKBP14 in ovarian cancer and evaluate whether FKBP14 is a molecular target for cancer therapy. We found that the FKBP14 mRNA 
level was significantly higher in ovarian cancer tissues than in normal tissues. FKBP14 expression was then 
knocked down in two ovarian cancer cell lines, SKOV3 and HO8910 cells, by a lentiviral short hairpin RNA 
(shRNA) delivery system. Reduced expression of FKBP14 markedly impaired the proliferative ability of ovarian cancer cells. Additionally, ovarian cancer cells infected with FKBP14 shRNA lentivirus tended to arrest in 
the G<sub>0</sub>/G<sub>1</sub> phase and undergo apoptosis. Moreover, knockdown of FKBP14 induced cell apoptosis via increasing the ratio of Bax to Bcl-2. These results indicated that FKBP14 might be a diagnostic marker for ovarian 
cancer and could be a potential molecular target for the therapy of ovarian cancer.
KW  - FKBP14; Ovarian cancer; Cell proliferation; Cell cycle; Cell apoptosis

DO  - 10.3727/096504016X14549667333963