@Article{096504016X14567549091341,
AUTHOR = {Bin Xiao, Chao Liu, Bing-tong Liu, Xuan Zhang, Rong-rong Liu, Xue-Wu Zhang},
TITLE = {TTF1-NPs Induce ERS-Mediated Apoptosis and Inhibit Human Hepatoma Cell Growth In Vitro and In Vivo},
JOURNAL = {Oncology Research},
VOLUME = {23},
YEAR = {2015},
NUMBER = {6},
PAGES = {311--320},
URL = {http://www.techscience.com/or/v23n6/57543},
ISSN = {1555-3906},
ABSTRACT = {Previous studies have shown that 5,2',4'-trihydroxy-6,7,5'-trimethoxyflavone (TTF1) is the primary anticancer constituent of the traditional Chinese medicinal plant <i>Sorbaria sorbifolia</i> (SS), which has been applied to 
treat cancer in China. In this study, we investigated the in vitro and in vivo antitumor effects and biological 
mechanisms of small-molecule TTF1 nanoparticles (TTF1-NPs). The effects of TTF1-NPs on cell growth and 
apoptosis were investigated using human hepatoma cells. The molecular changes associated with the effects of 
TTF1-NPs were analyzed by immunocytochemistry and Western blot analysis. The in vivo effect of TTF1-NPs 
was investigated using the HepG2 tumor xenograft model. We found that TTF1-NPs exhibited antitumor effects 
in vitro accompanied by induction of apoptosis in human hepatoma cells. Mechanistically, our data showed that 
TTF1-NPs induced apoptosis via endoplasmic reticulum stress (ERS) pathway in hepatoma cells. Moreover, 
inhibition of ERS activation blocked TTF1-NP-induced apoptosis in HepG2 cells. Finally, TTF1-NPs inhibited 
the growth of HepG2 xenograft tumors. Taken together, our results demonstrated that TTF1-NP-induced apoptosis was mediated at least in part by the ERS pathway and thus inhibited hepatoma tumor growth.},
DOI = {10.3727/096504016X14567549091341}
}