@Article{096504016X14570992647203,
AUTHOR = {Wei Zong, Chen Yu, Ping Wang, Lei Dong},
TITLE = {Overexpression of SASH1 Inhibits TGF-β1-Induced EMT in Gastric Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {1},
PAGES = {17--23},
URL = {http://www.techscience.com/or/v24n1/56606},
ISSN = {1555-3906},
ABSTRACT = {The epithelial–mesenchymal transition (EMT) is considered to be one of the critical steps in gastric cancer 
cell invasion and metastasis. SAM- and SH3-domain containing 1 (SASH1), a member of the SLY family of 
signal adapter proteins, is a candidate for tumor suppression in several cancers. However, the biological role 
of SASH1 in gastric cancer remains largely unknown. Therefore, the purpose of this study was to investigate 
the impact of SASH1 on the biological behavior of gastric cancer cells treated with transforming growth factor 
(TGF)-β1. In the current study, we provide evidence that SASH1 was lowly expressed in human gastric cancer 
cells, and TGF-β1 also inhibited the expression of SASH1 in TSGH cells. We found that SASH1 inhibited 
TGF-β1-mediated EMT in TSGH cells, as well as cell migration and invasion. Furthermore, SASH1 obviously inhibited the phosphorylation of PI3K and Akt in TGF-β1-stimulated TSGH cells. In summary, our 
study is the first to show that overexpression of SASH1 inhibits TGF-β1-induced EMT in gastric cancer cells 
through the PI3K/Akt signaling pathway. These results suggest that SASH1 may be a potential therapeutic 
target for the treatment of gastric cancer.},
DOI = {10.3727/096504016X14570992647203}
}