@Article{096504016X14597766487753,
AUTHOR = {Ye Lou, Lei Liu, Lihui Zhan, Xuewei Wang, Hua Fan},
TITLE = {miR-187-5p Regulates Cell Growth and Apoptosis in Acute  Lymphoblastic Leukemia via DKK2},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {2},
PAGES = {89--97},
URL = {http://www.techscience.com/or/v24n2/56954},
ISSN = {1555-3906},
ABSTRACT = {Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and causes a high rate of 
mortality in affected adults. Many subtypes of ALL exist with disruptions in distinct genetic pathways, including those regulated by miRNAs. Here we identify miR-187-5p as being highly upregulated in B-cell ALL and 
a driver of cellular proliferation and suppressor of apoptosis. We show that miR-187-5p directly targets the 
3'-UTR of DKK2 to mediate these effects. We further determine that inhibition of DKK2 by miR-187-5p in 
Nalm-6 B cells leads to inappropriate activation of Wnt/β-catenin signaling. Together, these findings reveal that 
the miR-187-5p–DKK2 pathway regulates Wnt/β-catenin signaling, cell growth, and apoptosis. Our findings 
provide the first evidence of a role for miR-187-5p in promotion of B-cell ALL.},
DOI = {10.3727/096504016X14597766487753}
}