@Article{096504016X14612603423511,
AUTHOR = {Jiahao Su, Meiqin Cai, Wensheng Li, Bo Hou, Haiyong He, Cong Ling,Tengchao Huang, Huijiao Liu, Ying Guo},
TITLE = {Molecularly Targeted Drugs Plus Radiotherapy and Temozolomide Treatment  for Newly Diagnosed Glioblastoma: A Meta-Analysis and Systematic Review},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {2},
PAGES = {117--128},
URL = {http://www.techscience.com/or/v24n2/56957},
ISSN = {1555-3906},
ABSTRACT = {Glioblastoma (GBM) is the most common primary malignant brain tumor that nearly always results in a bad prognosis. Temozolomide plus radiotherapy (TEM+RAD) is the most common treatment for newly diagnosed GBM. 
With the development of molecularly targeted drugs, several clinical trials were reported; however, the efficacy 
of the treatment remains controversial. So we attempted to measure the dose of the molecularly targeted drug 
that could improve the prognosis of those patients. The appropriate electronic databases (PubMed, MEDLINE, 
EMBASE, and the Cochrane Library) were searched for relevant studies. A meta-analysis was performed after 
determining which studies met the inclusion criteria. Six randomized, controlled trials (RCTs) were identified for 
this meta-analysis, comprising 2,637 GBM patients. The benefit of overall survival (OS) was hazard ratio (HZ), 
0.936 [95% confidence interval (CI), 0.852–1.028]. The benefit with respect to progression-free survival (PFS) rate 
was HZ of 0.796 (95% CI, 0.701–0.903). OS benefit of cilengitide was HZ of 0.792 (95% CI, 0.642–0.977). The 
adverse effects higher than grade 3 were 57.7% in the experimental group and 44.1% in the placebo group (odds 
ratio, 1.679; 95% CI, 1.434–1.967). The addition of molecularly targeted drugs to TEM+RAD did not improve 
the OS of patients with GBM; however, it did improve PFS in patients treated by cilengitide who could not get 
improvement in OS. The rate of adverse effects was higher in the experimental group than in the placebo group.},
DOI = {10.3727/096504016X14612603423511}
}