@Article{096504016X14611963142218,
AUTHOR = {Jiankang Zhu, Chongzhong Liu, Fengyue Liu, Yadong Wang, Min Zhu},
TITLE = {Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {3},
PAGES = {137--144},
URL = {http://www.techscience.com/or/v24n3/56959},
ISSN = {1555-3906},
ABSTRACT = {PFTK1 is a member of the cyclin-dependent kinase (CDK) family and is upregulated in many types of 
tumors. However, its expression and role in colon cancer remain unclear. In this study, we aimed to investigate 
the expression and function of PFTK1 in colon cancer. Our results showed that PFTK1 was highly expressed 
in colon cancer cell lines. The in vitro experiments demonstrated that knockdown of PFTK1 inhibited the 
proliferation, migration, and invasion of colon cancer cells as well as the epithelial-to-mesenchymal transition 
(EMT) progress. Furthermore, knockdown of PFTK1 suppressed the expression of Shh as well as Smo, Ptc, 
and Gli-1 in colon cancer cells. Taken together, these results suggest that knockdown of PFTK1 inhibited the 
proliferation and invasion of colon cancer cells as well as the EMT progress by suppressing the Sonic hedgehog 
signaling pathway. Therefore, these findings reveal that PFTK1 may be a potential therapeutic target for the 
treatment of colon cancer.},
DOI = {10.3727/096504016X14611963142218}
}