@Article{096504016X14635761799038,
AUTHOR = {Mei-han Liu, Shao-min Shi, Kai Li, En-qi Chen},
TITLE = {Knockdown of PFTK1 Expression by RNAi Inhibits the Proliferation and  Invasion of Human Non-Small Lung Adenocarcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {3},
PAGES = {181--187},
URL = {http://www.techscience.com/or/v24n3/56964},
ISSN = {1555-3906},
ABSTRACT = {PFTK1 (PFTAIRE protein kinase 1), also named CDK14 (cyclin-dependent kinase 14), is a member of the 
cell division cycle 2 (CDC2)-related protein kinase family. It is highly expressed in several malignant tumors. 
However, the role of PFTK1 in the progression of non-small cell lung cancer (NSCLC) is still elusive. In this 
study, we aimed to explore the expression and function of PFTK1 in NSCLC cells. Our results showed that 
PFTK1 was significantly upregulated in human NSCLC cell lines. Silencing the expression of PFTK1 inhibited the proliferation of NSCLC cells. In addition, silencing the expression of PFTK1 endowed NSCLC cells 
with decreased migration and invasion abilities, as well as epithelial–mesenchymal transition (EMT) progress 
in A549 cells. A mechanistic study showed that knockdown of PFTK1 inhibited the expression of β-catenin, 
cyclin D1, and c-Myc in A549 cells. In summary, we report that small interfering RNA (siRNA)-PFTK1 might 
inhibit the proliferation and invasion of NSCLC cells by suppressing the Wnt/β-catenin signaling pathway. 
Therefore, PFTK1 may represent a novel therapeutic target for the treatment of NSCLC.},
DOI = {10.3727/096504016X14635761799038}
}