@Article{096504016X14648701447850,
AUTHOR = {Zhe-liang Liu, Jiao Wu, Lin-xian Wang, Jin-feng Yang, Gao-ming Xiao, Hui-ping Sun, Yue-jun Chen},
TITLE = {Knockdown of Upregulated Gene 11 (URG11) Inhibits Proliferation, Invasion,  and b-Catenin Expression in Non-Small Cell Lung Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {3},
PAGES = {197--204},
URL = {http://www.techscience.com/or/v24n3/56966},
ISSN = {1555-3906},
ABSTRACT = {Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, was found to be 
involved in the development and progression of several tumors. However, the role of URG11 in human 
non-small cell lung cancer (NSCLC) has not yet been determined. Therefore, the aim of the present study 
was to explore the role of URG11 in human NSCLC. Our results found that URG11 was highly expressed in 
human NSCLC tissues compared with matched normal lung tissues, and higher levels were found in NSCLC 
cell lines in comparison to the normal lung cell line. Moreover, we also found that knockdown of URG11 
significantly inhibited proliferation, migration/invasion of NSCLC cells, as well as suppressed tumor growth 
in vivo. Furthermore, knockdown of URG11 suppressed the expression of β-catenin, c-Myc, and cyclin D1 
in NSCLC cells. Taken together, the study reported here provided evidence that URG11 downregulation 
suppresses proliferation, invasion, and β-catenin expression in NSCLC cells. Thus, URG11 may be a novel 
potential therapeutic target for NSCLC.},
DOI = {10.3727/096504016X14648701447850}
}