@Article{096504016X14648701447896,
AUTHOR = {Qian Li, Jing Jin, Jianghui Liu, Liqun Wang, Yutong He},
TITLE = {Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits  Esophageal Cancer Growth In Vivo},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {3},
PAGES = {205--214},
URL = {http://www.techscience.com/or/v24n3/56967},
ISSN = {1555-3906},
ABSTRACT = {We recently found that SLC39A5 (ZIP5), a zinc transporter, is overexpressed in esophageal cancer. Downregulation of ZIP5 inhibited the proliferation, migration, and invasion of the esophageal cancer cell line 
KYSE170 in vitro. In this study, we found that downregulation of SLC39A5 (ZIP5) by interference resulted 
in a significant reduction in esophageal cancer tumor volume and weight in vivo. COX2 (cyclooxygenase 2) 
expression was decreased and E-cadherin expression was increased in the KYSE170K xenografts, which was 
caused by the downregulation of ZIP5. However, we did not find that the downregulation of ZIP5 caused a 
change in the relative expressions of cyclin D1, VEGF (vascular endothelial growth factor), MMP9 (matrix 
metalloprotein 9), and Bcl-2 (B-cell lymphoma/leukmia-2) mRNA or an alteration in the average level of 
zinc in the peripheral blood and xenografts in vivo. Collectively, these findings indicate that knocking down 
ZIP5 by small interfering RNA (siRNA) might be a novel treatment strategy for esophageal cancer with 
ZIP5 overexpression.},
DOI = {10.3727/096504016X14648701447896}
}