@Article{096504016X14634208143021,
AUTHOR = {Ping Chen, Qing Jin, Qiang Fu, Peidong You, Xi Jiang, Qin Yuan, Huifang Huang},
TITLE = {Induction of Multidrug Resistance of Acute Myeloid Leukemia Cells by  Cocultured Stromal Cells via Upregulation of the PI3K/Akt Signaling Pathway},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {4},
PAGES = {215--223},
URL = {http://www.techscience.com/or/v24n4/56968},
ISSN = {1555-3906},
ABSTRACT = {This study aimed to investigate the role of the PI3K/Akt signaling pathway in multidrug resistance of acute 
myeloid leukemia (AML) cells induced by cocultured stromal cells. Human AML cell lines HL-60 and U937 
were adhesion cocultured with human bone marrow stromal cell line HS-5 cells. Such coculturing induced 
HL-60 and U937 cells resistant to chemotherapeutic drugs including daunorubicin (DNR), homoharringtonine 
(HHT), and cytosine arabinoside (Ara-C). The coculturing-induced resistance of AML cells to DNR, HHT, and 
Ara-C can be partially reversed by inhibition of the PI3K/Akt signaling pathway. Clinically, AML patients with 
a low level of PTEN and a high level of CCND1 had high relapse rates within 1 year, and newly diagnosed 
AML patients with extramedullary infiltration had a low level of PTEN. This study confirms the involvement 
of the PI3K/Akt signaling pathway in multidrug resistance in AML cells induced by stroma and suggests that 
the expression of PTEN and CCND1 may be a prognostic indicator for AML.},
DOI = {10.3727/096504016X14634208143021}
}