@Article{096504016X14648701447931,
AUTHOR = {Ruoyu Wang, Heming Li, Xuefen Guo, Zhe Wang, Shanshan Liang, Chengxue Dang},
TITLE = {IGF-I Induces Epithelial-to-Mesenchymal Transition via the IGF-IR–Src– MicroRNA-30a–E-Cadherin Pathway in Nasopharyngeal Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {4},
PAGES = {225--231},
URL = {http://www.techscience.com/or/v24n4/56969},
ISSN = {1555-3906},
ABSTRACT = {Recurrence and distant metastasis are the most common cause of therapeutic failure in nasopharyngeal carcinoma (NPC) patients. Insulin-like growth factor I (IGF-I) can induce epithelial-to-mesenchymal transition 
(EMT) in many epithelial tumors; however, whether IGF-I can enhance NPC metastasis by EMT and the 
mechanisms remain unclear. Herein, we have identified that IGF-I could induce EMT and enhance migration 
ability in NPC cell lines. Furthermore, both Src inhibitor and microRNA-30a (miR-30a) inhibitor reversed 
IGF-I-induced EMT, suggesting the involvement of an IGF-IR–Src–miR-30a–E-cadherin pathway in IGF-Iinduced EMT in NPC cell lines. Overall, the results of the present study may provide more useful information 
regarding the mechanisms of the IGF-IR signaling pathway in the regulation of NPC metastasis. Both Src 
kinase and miR-30a can be potential biomarkers for selecting high risk of metastasis in NPC patients.},
DOI = {10.3727/096504016X14648701447931}
}