@Article{096504016X14648701447977,
AUTHOR = {Guoqiang Zhang, Zengyan Liu, Yong Han, Xiaohong Wang, Zhenlin Yang},
TITLE = {Overexpression of miR-509 Increases Apoptosis and Inhibits Invasion  via Suppression of Tumor Necrosis Factor-α in Triple-Negative Breast Cancer Hs578T Cells},
JOURNAL = {Oncology Research},
VOLUME = {24},
YEAR = {2016},
NUMBER = {4},
PAGES = {233--238},
URL = {http://www.techscience.com/or/v24n4/56970},
ISSN = {1555-3906},
ABSTRACT = {Triple-negative breast cancer (TNBC) is associated with high recurrence rates of metastasis and death. miR-509 
has been reported to be a tumor suppressor in many cancers, but its effect in TNBC has not yet been identified. In this article, we explored the effects of miR-509 on the malignant phenotype of TNBC cells, including 
proliferation, apoptosis, migration, and invasion. We transiently transfected TNBC cells, Hs578T, with miR-509 
mimic. Upon transfection, the expression of miR-509 was upregulated about 50-fold compared with cells 
transfected with scramble mimic. Overexpression of miR-509 inhibited cell proliferation, induced cell apoptosis, and suppressed cell invasion of Hs578T cells. Moreover, tumor necrosis factor-α (TNF-α) was involved 
in miR-509-mediated suppressive effects of TNBC cells, as being treated with TNF-α could partially abolish 
the suppressive effects of miR-509. Collectively, these data suggest that miR-509 could reverse the malignant 
phenotype of TNBC cells, probably by suppressing TNF-α.},
DOI = {10.3727/096504016X14648701447977}
}